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(4) increased hepatic and renal urea cycle intermediates suggesting hypercatabolism and upregulation of the urea cycle independent of impaired renal clearance of nitrogenous waste

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Our bioinformatics analysis using public high-throughput database revealed a significant downregulation of CRAT in tumor tissues of ovarian cancer (OC), as compared to corresponding normal tissues, implying that CRAT may play a role in the progression of OC