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These changes typically become noticeable within 8 to 12 weeks and continue to develop over the course of a full 3 to 4 month cycle

The GSH/GSSG-Glo Assay is a luminescence-based system used to detect and quantify glutathione in both the oxidized and reduced states

Following an initial screening period, patients were randomized (using a web/voice interactive response system) 1:1:1 to glycopyrrolate/eFlow CS 25mcg twice daily (BID), glycopyrrolate/eFlow CS 50mcg BID, or placebo BID in GOLDEN-3 and -4, and 4:3 to glycopyrrolate/eFlow CS 50mcg BID or tiotropium 18mcg once daily (via HandiHaler) in GOLDEN-5 (Figure 2)

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