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Elevated serum zonulin levels, as well as bacterial dysbiosis and a leaky gut barrier, have been observed in patients with rheumatoid arthritis, while subclinical intestinal inflammation has been observed in patients with ankylosing spondylitis [74, 75]
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THs bound to these proteins are inactive and in a dynamic equilibrium with the circulating levels of free T4 (FT4) and free T3 (FT3), which instead enter the cells of the target tissues, exploiting the THs biological effects