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This was highlighted in a recent study performed in a mouse model of obesity-induced T2DM, in which an 8-week exendin-4 treatment, starting 3 days post-stroke, improved neurological recovery by reversing T2DM-induced atrophy of parvalbumin-positive GABAergic interneurons, which play a key role in neuroplasticity [8]

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Models should prioritize clinically interpretable structures (e.g., tree models, Bayesian networks, or explainable ensemble models) to facilitate integration into shared decision-making in the clinic