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Increased cancer risk is a common feature of chronic exposure to certain metals

Figure 2 To unravel the precise signaling pathway linking metformin to the NR4A nuclear receptor family requires further studies, but it is worthy of note that the orphan receptor, Nur77, regulates LKB1 localization and is also important for the regulation of glucose uptake into C212 mouse muscle cells (184, 185)

coli via the QIAFILTER plasmid purification method (QIAGEN, Tegelen, The Netherlands) and then transfected into Sf9 cells (Genetime ExCell Technology, Shanghai, China

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