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In the alkaline environment of the small intestine, R-proteins are degraded by pancreatic enzymes, freeing vitamin B 12 to bind to intrinsic factor (IF), a protein secreted by specialized cells in the stomach (parietal cells)

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However, it is speculated that the impact of mitochondrial dysfunction on energy metabolism, calcium control, and membrane excitability can interfere with intestinal homeostasis, weaken immune responses, and cause the chronic inflammation seen in IBD (72)