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Selective cytotoxicity of the NAMPT inhibitor FK866 toward gastric cancer cells with markers of the epithelial-mesenchymal transition, due to loss of NAPRT

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In this context, the gut-derived GLP-1 crosses the bloodbrain barrier (BBB) and binds to receptors in the circumventricular organs of the brainstem, transmitting metabolic information to the neurons responsible for feeding behaviour (e.g., in the NTS and hypothalamus) [2,10,20,21]