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When to Contact Your Provider About Mood Changes Immediate medical attention is warranted if you experience suicidal thoughts, severe hopelessness, or rapid changes in mood while on GLP-1 medication

They can be slightly uncomfortable and produce a tingling sensation at the injection site

Upon binding to G-protein-coupled receptors on the beta cells, intracellular cAMP level is elevated and the protein kinases, Epac1 and 2, are activated, which leads to an increase of insulin secretion