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Moreover, administration of a liver-targeted TR-selective agonist increases GLP-1 and insulin levels and alleviates hyperglycemia in diet-induced obesity

Clinical Evidence for Non-Diabetic GLP-1 Use The landmark STEP trials (20212022) enrolled thousands of non-diabetic adults with overweight or obesity and measured semaglutide's effect on weight loss alone

IGF-1 IGF 1 refers to Insulin-Like Growth Factor, a natural hormone found in the body working in close relation to natural Growth Hormone production

In vivo, it decreased the levels of NF-B p65 and IB phosphorylation while increasing the expression of PPAR, which could potentially play an anti-inflammatory role in the progression of colitis [238]