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They are the only peptide on this list with multiple randomized controlled trials for joint pain in human patients

In many cases, these alternatives can also be used alongside ALA for broader support

Unfortunately, VEGF can also be detrimental because its overexpression can cause inflammation in the nervous system, which in turn can lead to BBB leakage, promote the production of pro-inflammatory cytokines and the occurrence of neurodegeneration (Claire and Larrive 2017