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Semaglutide Safety in Hypothyroidism and Hyperthyroidism Patients with hypothyroidism (underactive thyroid) on stable levothyroxine replacement can typically use semaglutide safely, provided TSH remains controlled and dose adjustments are made as weight decreases

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While animal studies have not shown direct harm to offspring, the absence of human lactation studies means healthcare providers typically recommend delaying GLP-1 treatment until breastfeeding ends