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Body-composition shifts tend to emerge later, and connective-tissue benefits tendon resilience, joint comfort, recovery typically take several months to become apparent

#4: Valproic acid or phenobarbital (whichever you didnt choose as #3)

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The restraints were derived from (i) NOE restraints from intermolecular and intramolecular cross-peaks in NOESY spectra (described in NMR spectroscopy section), (ii) TALOS derived p53 TAD2 and FOXO4-DRI backbone dihedral angles, (iii) hydrogen bond restraints (regions p53 residues 4752, FOXO4-DRI residues 918