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In mammalian cells, -glutamylcysteine synthetase is effectively inhibited by a GSH feedback, whereas glutathione synthetase is not subject to the negative feedback 9,30
These disruptions are not limited to sleep quantity but extend to qualitative aspects, such as diminished delta power during slow-wave activity, fewer and shorter NREM/REM episodes, and increased latency to these stages (Mander et al., 2017)
doi: 10.1200/jco.2015.33.15_suppl.9068 144 WeiBRHooverSBPeerCJDwyerJEAdissuHAShankarappaPet al
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