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The depicted antioxidant effects of SE, AST, or PHA alone or in combination provided a possible explanation for the observed anti-inflammatory actions of these agents, since ROS are the chief initiator for the activation of inflammatory pathways (Mostafa et al

AARS1 binds directly to lactate, catalyzes the adenosine triphosphate (ATP)-dependent synthesis of lactate-AMP and mediates widespread lysine lactylation, including that of p53