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Astaxanthin has demonstrated an excellent safety profile in numerous clinical studies, with no significant adverse effects reported even with long-term use

These observations suggest that AOD9604 may interact with cartilage metabolism and joint remodeling pathways, making it a candidate tool for investigating chondrocyte activity, matrix turnover, and osteoarthritic progression in preclinical models

Stages of Knee OA Progression Unless treated in its early stages, knee OA becomes a progressive disorder that leads to severe degeneration of the knee joint over time

Int J Mol Sci 22(4):1599 Gombik K, Detka J, Kukla-Bartoszek M, Maciejska A, Budziszewska B (2022) Changes in regulators of lipid metabolism in the brain: a study of animal models of depression and hypothyroidism