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Based on their biogenesis and size, EVs are classified into three main subtypes: Exos (30150 nm in diameter), microvesicles (1501000 nm in diameter), and apoptotic bodies (502000 nm in diameter) (recently reviewed [54,55,56]

doi: 10.3390/nu16020233 574 PoppasA

Therefore, factors such as dermal delivery systems, stability, and irritation potential must be carefully balanced when formulating cosmetic products to ensure both efficacy and skin compatibility