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In our investigations, we observed that robust angiogenesis, characterized by grossly visible neovascularization and a marked increase in CD31-positive luminal structures by immunohistochemistry, was a prominent histological feature of healing in animal models of tissue injury treated with BPC157

Research published in JCI Insight describes tirzepatide as an "imbalanced and biased" dual agonist, meaning it shows equal affinity for the GIP receptor compared to native GIP but approximately 5-fold weaker affinity for the GLP-1 receptor compared to native GLP-1