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Conversely, a cohort study using standard dietetic advice to produce intentional weight loss in older adults with T2D demonstrated that every 1 kg of weight loss was an associated 34 months survival prolongation [64], and a meta-analysis of RCTs assessing the impact of intentional weight loss on mortality found a 15%, although the mean age of participants was 52 years [65]

2002;282:H1760-1767

We next asked whether autoantibody-induced arthritis leads to sensory nerve hyperexcitability and which neuronal types are affected

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