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In HK-2 cells and C57BL/KsJ mice, the kidney jury restoration after ferroptosis inhibition via the Nrf2/HO-1 signaling pathway has been sufficiently confirmed in the research on the therapeutic mechanism of quercetin, vitamin D receptor, umbelliferone, etc [77, 82, 156]

doi: 10.1186/s12929-024-01025-6

The PCA score plot showed that the first principal component (PC1) and second principal component (PC2) accounted for 36% and 24.3% of the total variance, respectively (Fig