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These observations provide a novel theoretical foundation for the treatment of OP via targeting the GM5-HT axis, indicating that suppression of gut-derived 5-HT biosynthesis may serve as a promising anabolic approach for bone health

Acknowledgments The authors would like to thank the magnetic resonance imaging technologists for their valuable assistance in acquiring the imaging data

Research shows it may be effective for improving insulin resistance, reducing body weight and lowering lipid levelssuggesting berberine as a natural option for supporting weight loss

In the absence of such a marker, there is value to understand what (if any) clinical factors are associated with increased risk of PDAC amongst those who are using GLP-1RAs