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Common genetic variants in detoxification and response genes such as CYP1A2, CYP3A4, GSTM1, GSTA1, GSTP1, UGT1A1, XPC, GSDMB, and IL13 can increase susceptibility to mitochondrial damage, organ injury, or asthma from mycotoxins

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Studies show liposomal forms increase plasma glutathione levels by up to 28% in just 2 weeks

Based upon post-marketing reports, children younger than 12 years old appear to be more susceptible to the respiratory depressant effects of codeine, particularly if there are risk factors for respiratory depression