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Increased export of GSH can be a part of GBM cells strategy to protect themselves from oxidative damage induced by this therapeutic approach, mitigating the harmful effects of ROS in the surrounding TME

Whether the short fragment reproduces those CNS effects has not been demonstrated equivalently, so neuro claims for TB-500 rest largely on parent-molecule inference

It was found that more patients in the LIR group than the placebo group maintained their weight loss by 5%, which indicated that LIR 3.0 mg/d is expected to improve the maintenance of weight loss (93)