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Obesity is a multifaceted disease that contributes directly and indirectly to atherosclerotic CVD, heart failure, atrial fibrillation and multiple CVD risk factors, including dyslipidaemia, type 2 diabetes, hypertension and sleep disorders (Figure)

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In this Review, we discuss recent findings regarding the regulatory mechanisms, physiological roles and pathological importance of lipogenesis in multiple tissues such as adipose tissue and the liver, as well as the immune and nervous systems