do not combine dpp-4 inhibitors with glp-1 receptor agonists recommendation The Role of in the Treatment Algorithm of Type 2 Diabetes Mellitus: When to Select, What to Expect Can DPP-4 (Dipeptidyl Peptidase-4) inhibitors

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There were no statistically significant increases in the risks of all-type hypoglycemia and severe hypoglycemic episodes (69) (Grade A)

GLP-1-activated PKA inhibits voltage-gated potassium channels, prevents membrane repolarization, and prolongs VDC channel opening to promote Ca 2+ inward currents, contributing to GLP-1 stimulate insulin secretion, and the antagonistic effect of GLP-1R activation on Kv currents in cells requires transactivation of epidermal growth factor receptors, accompanied by signal conduction of cAMP/PKA and phosphatidylinositol-3-kinase (PI3K)/PKC signaling (MacDonald et al., 2003)

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