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Ge, S., Song, L

As a triple agonist targeting GLP-1, GIP and glucagon receptors, it delivers comparable weight loss around 24% body weight reduction over 48 weeks in clinical trials while the GIP pathway actively preserves muscle

18 FGF-18 has been particularly associated with increased cartilage matrix deposition and cell survival, as it elevates ERK-dependent transcription of genes that underlie proteoglycan and collagen synthesis

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