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Adjust doses based on tolerance and response

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It is noteworthy that, multiple sex hormone receptors (ER/, PR-A/B, and AR) all belong to the nuclear receptor superfamily and share common structural domains: the C-terminal ligand-binding domain, the variable N-terminal with a transcriptional activation function domain, the central DNA-binding domain, and the hinge region

Taking into consideration that mutants affected in glutathione biosynthesis exhibited a susceptible phenotype while, under our conditions, none of the tested sulfate transporter mutants did so, the latter did not seem to affect glutathione homeostasis sufficiently to result in increased susceptibility to AITC