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In these situations, replacing both fluids and electrolytes may help support rehydration

Peripherally, they primarily act on the pancreas and gastrointestinal tract, stimulating insulin secretion and inhibiting glucagon secretion when blood glucose levels rise, thereby exerting a hypoglycemic effect [60]

Weakness may result from hypoglycaemia (especially with sulphonylureas or insulin), appetite suppression leading to insufficient energy intake, or gastrointestinal side effects causing dehydration