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Understanding how GSH is synthesized helps explain: (a) why intracellular GSH, and OxS levels are corrected by GlyNAC and not by isonitrogenous placebo (i.e., that increasing protein supplementation per se does not improve GSH deficiency in aging)

A 2% niacinamide, 23% TXA, 4% -arbutin, and 4% ferment filtrate serum and a 4% niacinamide, 3% -arbutin, 1% bisabolol, and 0.05% retinaldehyde cream were also effective in treating hyperpigmentation issues [130]