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Glutathione depletion prevents diet-induced obesity and enhances insulin sensitivity

Hepatic Uncommon (0.1% to 1%): Acute gallbladder disease (cholelithiasis, biliary colic, cholecystectomy) Hypersensitivity Common (1% to 10%): Hypersensitivity reactions (e.g., urticaria, eczema) Postmarketing reports : Anaphylaxis, angioedema Immunologic Very common (10% or more): Anti-drug antibodies (up to 51%) Common (1% to 10%): Neutralizing antibodies Local Common (1% to 10%): Injection site reactions Metabolic Very common (10% or more): Hypoglycemia (up to 19%), decreased appetite (up to 11%) Common (1% to 10%): Hyperglycemia Hypoglycemia (glucose level less than 54 mg/dL) occurred more frequently when this drug was used in combination with a sulfonylurea (up to 13% of patients in a clinical trial)

Drugs (e.g., calcium channel blockers, opiates, antispasmodics, antidepressants) [9] altered autonomic outflow and bowel muscle contraction [10] Endocrine pathology (e.g., hypothyroidism) downregulated bowel motility Neurological pathology (e.g., spinal injury, enteric neuropathy) disease or trauma of bowel innervation Ineffective peristalsis difficult passage of stool regardless of stool consistency sensation of incomplete and irregular bowel emptying References: [10] [11] Approach to management Manage complications Identify and treat fecal impaction