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ROC analysis showed high diagnostic sensitivity (96.7%) and low specificity (53.3%) for GDF15 at a cutoff of 478.31 pg/mL (AUC = 0.922, 95% CI: 0.8750.969, p 0.05)

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Recent studies have demonstrated that p53 contributes to iron homeostasis by transcriptionally regulating the expression of solute carrier family 25 member 28 (SLC25A28) and ferredoxin reductase (FDXR) to enhance the susceptibility of cells to ferroptosis [127, 128]

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