For instance, monoterpene nerol activates OR2W3, which triggers Ca 2+ influx and then co-activates TMEM16A and CFTR, ultimately leading to smooth muscle relaxation and bronchodilation ( Figure 3A )
Lipolysis Enhancement and Lipogenesis Inhibition In obese Zucker rats, daily oral administration of AOD9604 significantly increased lipolytic activity in adipose tissue compared to controls, establishing direct adipocyte-level lipolysis stimulation as a key mechanism of action in pre-clinical models
It has been shown using various atherosclerosis animal models that GLP-1RA therapy is associated with a reduction in atherosclerotic plaques, prevention of aorta intima-media thickening, improvement in vascular endothelial function, reduction of the necrotic zone and an increase of the fibrous component in the plaque and plaque stabilisation
Lai ZZ, Yang HL, Ha SY, et al