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doi: 10.1016/j.jtemb.2018.02.024 113 StoneJR

Two phase 3 RCTs (STEP1 and STEP 2) regarding overweight or obese patients with diabetes mellitus, proved that semaglutide 2.4mg subcutaneously weekly was superior to placebo, as far as body-weight reduction is concerned, 41,42 while similar results were derived from another phase 3 trial, comparing oral semaglutide with liraglutide in diabetic overweight patients, where semaglutide achieved significantly greater weight reduction than liraglutide or placebo (NCT02863419-PIONEER 4)