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HGF/c-Met signaling is a well-established oncogenic pathway: c-Met is amplified or overexpressed in multiple cancers (gastric, lung, renal, hepatocellular) HGF/c-Met activation promotes tumor cell proliferation, survival, invasion, and metastasis c-Met inhibitors are FDA-approved cancer drugs (cabozantinib, crizotinib, capmatinib) A compound that potentiates HGF/c-Met signaling raises theoretical concerns about promoting tumor growth or transformation with chronic use

This makes it safer for longer-term use and eliminates concerns about developing insulin resistance

Scenario 1 (Using 1ml of Water): If you add 1ml (which is 100 units on a U-100 insulin syringe) of bacteriostatic water to a 1mg (1000mcg) vial of IGF-1 LR3, your final solution will have a concentration of 1000mcg per 1ml

Unreconstituted powder can be stored at room temperature but maintains longer stability when refrigerated