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The use of lactate for energy has been proposed to occur within the mitochondria where it can be oxidized to pyruvate by mitochondrial LDH which localizes to the inner mitochondrial membrane
A propensity-matched analysis across seven solid tumors. Journal of Clinical Oncology
Again, this is typically dose-dependent and often resolves as water retention normalizes or with adjustments to the research protocol
In the condition of oxidative stress, nitric oxide was produced through the activation of inducible isoform iNOS with formation to elevate concentration of nitric oxide and thus of peroxynitrite (ONOO )
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