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Nat Protoc 4:4457 Petruzzelli R, Catalano F, Crispino R, Polishchuk EV, Elia M, Masone A et al (2025) Prion protein promotes copper toxicity in Wilson disease

Obesity is a significant health risk, as it increases the risk of developing cardiovascular diseases, diabetes, hypertension, and other medical conditions

In the context of early brain injury following subarachnoid hemorrhage (SAH), topiramate significantly reduced the elevated levels of TNF-, IL-1, and IL-6 induced by SAH, suggesting that topiramate may exert neuroprotection via its anti-inflammatory effects ( In an experimental model of abdominal aortic aneurysm, topiramate markedly downregulated pro-inflammatory M1 macrophage activity, reduced the expression of TNF-, IL-1, and matrix metalloproteinase-9, and promoted a phenotypic shift of macrophages from M1 to M2, thereby mitigating pro-inflammatory activity and enhancing tissue repair processes ( These studies collectively suggest that topiramate exerts significant neuroprotective effects across various pathological models through its potent anti-inflammatory properties

Supports alpha brain wave productionthose are the waves associated with relaxed alertness