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Furthermore, treatment with Fer-1 relieved the inhibition of PDO growth that had been induced by ACTL6A KD, and enabled organoids regained a cystic structure (Fig

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They modulate redox-sensitive pathways such as those mediated by mitogen-activated protein kinase (MAPK), phosphatidylinositol 3-kinase (PI3K), and some tyrosine phosphatases