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Impairment in Glutathione peroxidase 4 (GPX4) function, which attenuates cellular redox defense, i s also associated with cartilage extracellular matrix (ECM) damage (Miao et al., 2022) implying targeting ferroptosis as a promising new direction for possible interventions in OA pathogenesis
They also participated in the papers drafting, revision or critical review, gave their final approval for the version that would be published, decided on the journal to which the article would be submitted, and made the responsible decision to be held accountable for all the aspects of the work
Antagonism of CB1 causes a dose-dependent rise in corticosterone levels in mice (102)
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