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Hypertrophy was induced by treating cardiac myocyte with PE (50 M) for 48 h, followed by incubation with or without PQQ (100 M) for an additional 24 h

Anticarcinogenic action of quercetin by downregulation of phosphatidylinositol 3-kinase (PI3K) and protein kinase C (PKC) via induction of p53 in hepatocellular carcinoma (HepG2) cell line

This data suggests that the variants induce a different downstream transcriptional programme in response to metabolic stress, in line with our observation of a significantly reduced expression of the cytokine Ccl2 in starved C3H10T1/2 adipocytes when we overexpressed the R72 compared to the P72 variant