These interactions appeared to align with an increase in muscle fiber size, overall muscle mass, and hence, a potential boost in skeletal muscle strength during this mouse-based study
Dysfunction or disruption of the redox buffer has been implicated in various diseases and the implications make GSH, GSSG, and their related systems valid and effective targets for medicinal chemistry interventions
Alzheimers disease (AD), the most common form of dementia worldwide 270,271 , is characterized at the molecular level by the accumulation of A plaques, tau neurofibrillary tangles (NFTs), declined NAD + levels, mitochondrial stress, and impaired mitophagy, occurring first in the medial temporal lobe and eventually spreading to temporal and parietal cortices, and cortex 112,242,243,270,271,272
Wang W, Zhao F, Ma X, Perry G, Zhu X (2020) Mitochondria dysfunction in the pathogenesis of Alzheimers disease: recent advances