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Since D2HG and L2HG are indistinguishable in standard LC-MS, to determine which 2HG enantiomer(s) is affected, we adapted a chiral N-(p-toluenesulfonyl)-L-phenylalanyl chloride (TSPC) derivation followed by liquid chromatography with tandem mass spectrometry (LC-MS/MS) analysis 24,40

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Erinacine A, for example, has been shown to increase nerve growth factor (NGF) levels in the brain, promoting neurogenesis and neuronal survival [136]

EGRIFTA WR is not indicated for use in pediatric patients with open or closed epiphyses