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In May 2026, Phase 3 topline results from the TRIUMPH-1 trial across 2,339 participants showed an average 28.3 percent body weight reduction over 80 weeks at the highest dose, with 45.3 percent of those participants losing at least 30 percent of body weight a threshold previously achievable only through surgery

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Prepared receptor models were then processed in System Builder to define the simulation environment, assign default physiological ionization conditions, and were then subjected to a final restrained minimization to remove steric clashes and ensure structural relaxation before virtual screening calculations