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PloS ONE 16 , e0249316 (2021)

Stoichiometry of the TCA Cycle The overall stoichiometry of the TCA cycle is: acetyl-CoA + 3NAD + + FAD + GDP + P i + 2H 2 O 2CO 2 + 3NADH + FADH 2 + GTP + 2H + + CoASH Role of Lactate as Driver for TCA Cycle Activity The lactate produced by anaerobic glycolysis does not simple serve as an intracellular carbon source for hepatic glucose production via gluconeogenesis

A Physiological Toxicokinetic Model for 1,3-Butadiene in Rodents and Man: Blood Concentrations of 1,3-Butadiene, Its Metabolically Formed Epoxides, and of Haemoglobin Adducts--Relevance of Glutathione Depletion. Toxicology 113 (1-3): 300305

& Iqbal, M.A