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While some authors suggest it may work by activating L-type calcium channels through an alternative mechanism, others have found no clinical benefit and do not universally recommend its use.[4,5,7] Additionally, a systematic review found no relevant human studies and was limited to only animal modules that found no effect on mean arterial pressure or overall survival.8 If used, dosing typically begins with 5-10 mg intermittent boluses followed by a continuous infusion of 5-10 mg/hr if a response is noted