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The first is the glutamate receptor mechanism, which induces ROS production by activating calpain 1, phospholipase A2, and nitric oxide synthase (NOS) after glutamate binds to NMDARs [90]

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GPx3 activity in patients with submaximal baseline GPx3 levels (subgroup IV) Subgroup IV consisted of patients with GPx3 baseline activity below 250 U/l ( n = 32)