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The persistence of hyperglycemia in diabetes triggers a sequence of local metabolic, vascular, and neurochemical modifications, which ultimately culminate in vascular disease and microangiopathy [25]

Furthermore, additional receptors, such as TLR3, TLR4, and IFNAR1, play roles in initiating necroptosis, involving adapter molecules such as TIR domain-containing adapter molecule 1 (TICAM1, also known as TRIF) or RIHM-containing proteins Z-DNA binding protein 1 (ZBP1) [125, 126]

It is important to also highlight that levels of myo-inositol in the follicular fluid are good marker of oocyte quality in animal study (19) but also in women during IVF procedure (20)