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Of those reporting no SGLT2i use at baseline, increasing numbers of participants started SGLT2i during the trial, with a greater proportion starting SGLT2i in the placebo (approximately 10% at 18 months and approximately 20% at 36 months) than in the semaglutide group (approximately 5% at 18 months and approximately 10% at 36 months

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Typical titration schedule in trials: Start at 2 mg weekly Increase every 4 weeks: 2 mg 4 mg 6 mg 9 mg or 12 mg (depending on target dose) This means it takes 3-4 months to reach the maximum dose Meaningful weight loss becomes apparent after reaching therapeutic doses and maintaining them for several weeks