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Abstract This state-of-the-art review explores the relationship between depression and diabetes, highlighting the two-way influences that make treatment challenging and worsen the outcomes of both conditions

Wegovy is a glucagon-like peptide-1 receptor agonist (also called a GLP-1 medication) that has been approved by the Food and Drug Administration (FDA) for the following indications: to help with weight loss and long-term weight management in certain adults and children who are overweight or have obesity to reduce the risk of major adverse cardiovascular (CV) events (heart attack, stroke, or CV death) in adults with established cardiovascular disease who are overweight or have obesity to treat metabolic-associated steatohepatitis (MASH) in adults with moderate-to-advanced liver fibrosis Wegovy is typically prescribed as part of a treatment plan that includes a healthy, reduced-calorie diet and regular exercise

In the only head-to-head trial, Wegovy achieved 15.8% weight loss compared with 6.4% for Saxenda over 68 weeks

However, the severity and fatal outcomes of some of these reports warrant further investigation