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Casanovas, O., Hicklin, D

Philp and colleagues (FASEB J, 2003) showed the LKKTETQ actin-binding site alone is sufficient to promote endothelial cell migration and angiogenesis, and Bock-Marquette and colleagues (Nature, 2004) reported activation of integrin-linked kinase and Akt with cardiomyocyte and epicardial cell migration in mouse cardiac injury models, indicating a signalling role separate from actin buffering

Such challenges have been worked on by investigators from the Alzheimers, Parkinsons and prionopathy fields for decades, and we suggest that emerging methods for interrogating protein misfolding could be very applicable to research into the foundations of MS as well

Pharmaceutical peptides undergo extensive clinical testing before approval