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Compounding the issue, GLP-1RAs delay gastric emptying, which may reduce the absorption of oral medications, including isotretinoin and oral contraceptivespotentially compromising both acne treatment and pregnancy prevention

In the OASIS-4 trial, people with obesity taking the 25 mg oral semaglutide pill once a day, in addition to making lifestyle changes, lost about 16.6 percent of their body weight over 64 weeks, compared to 2.7 percent with placebo, says LaValle

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