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Other challenges included the non-availability of substances, or precursors, that could produce glutathione in the body after administering them and insignificant amounts of these substances reaching the site of physiological activity after administration, Bush explained

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Fecal excretion of total carnitine was less than 1% of the administered dose.10 After attainment of steady-state following 4 days of oral administration of levocarnitine tablets (1980 mg q12h) or oral solution (2000 mg q12h) to 15 healthy male volunteers, the mean urinary excretion of levocarnitine during a single dosing interval (12h) was about 9% of the orally administered dose (uncorrected for endogenous urinary excretion)

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